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Homophilic binding regulates apoptosis



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TitleHomophilic binding regulates apoptosis Contact
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Mary O'Reilly DescriptionPECAM is a glycoprotein that binds to glycans on other copies of PECAM on the same or other cells, regulating apoptosis. This illustration was created for the February, 2010 Functional Glycomics Update (Nature Publishing Group) to accompany a highlight of the paper by Kitazume S, et al. “{alpha}2,6-sialic acid on platelet endothelial cell adhesion molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling.” J Biol Chem. 2010 285, 6515-21. KeywordsPECAM, apoptosis, homophilic, angiogenesis, platelet endothelial cell adhesion molecule, sialic acid, carbohydrate Media Color Categories Medical, Science Subject(s) Human, Molecular, Pharmaceutical, Cartoon, Institutional, Processes, Technology Medical Illustration
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