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"Achieving multivalency with beads on a string"Image by Mary O'Reilly (visit gallery »)
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TitleAchieving multivalency with beads on a string Contact
»Mary O'Reilly DescriptionThis illustration was prepared for a lecture on multivalency, and describes a pseudopolyrotaxane, consisting of several carbohydrate-modified cyclodextrin molecules assembled onto a carbon chain. Positively-charged viologen “speed bumps” on the chain maintain spacing between the cyclodextrins, while allowing rotational and translational degrees of freedom.
Belitsky JM, Nelson A, Hernandez JD, Baum LG, Stoddart JF. Multivalent interactions between lectins and supramolecular complexes: Galectin-1 and self-assembled pseudopolyrotaxanes. Chemistry&Biology, 2007, 14, 1140-51.
Keywordsrotaxane, pseudopolyrotaxane, cyclodextrin, galectin, glycobiology, carbohydrate, chemical biology, multivalency, self-assemply, supramolecular Media Color Categories Science, Technical Subject(s) Human, Molecular, Pharmaceutical, Cartoon, Institutional, Processes, Technology