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Neutralizing galectins with polyrotaxanes



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TitleNeutralizing galectins with polyrotaxanes Contact
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Mary O'Reilly DescriptionThis illustration was prepared for a lecture on multivalency, and describes how pseudopolyrotaxane with pendant carbohydrate ligands can cross-link and aggregate galectin-1 while occupying its binding site, thus neutralizing a lectin that can play a role in promoting cancer metastasis.
Belitsky JM, Nelson A, Hernandez JD, Baum LG, Stoddart JF. Multivalent interactions between lectins and supramolecular complexes: Galectin-1 and self-assembled pseudopolyrotaxanes. Chemistry&Biology, 2007, 14, 1140-51.
 Keywordsrotaxane, pseudopolyrotaxane, cyclodextrin, galectin, glycobiology, carbohydrate, chemical biology, multivalency, self-assemply, supramolecular Media Color Categories Medical, Science Subject(s) Human, Molecular, Pharmaceutical, Cartoon, Institutional, Processes, Technology Medical Illustration
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