Dr Jon HerasDescriptionPPARs (Peroxisome proliferator-activated receptor) are a group of receptor proteins that function as transcription factors regulating the expression of genes. They play essential roles in the regulation of cellular differentiation, development, and metabolism.
They are being targeted as a way of producing a “thin pill” for humans which would modulate the activity of the PPAR-delta, agonism of which changes the body’s fuel preference from glucose to lipids, thereby reducing the body’s fat content.
The molecule shown is a potential pharmaceutical, a ligand which binds to a human PPAR-delta receptor. Its molecular formula is C27 H36 F2 N2 O4.
Carbon is represented in grey, oxygen in red, nitrogen in blue, and fluorine in turquoise. KeywordsPPAR, peroxisome, proliferators, receptor, activation, modulation, metabolism, human, thin, pill, fat, glucose, sugar, pharmaceutical, structure, molecular, obesity, diet, weight lossMedia
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